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Events Detail:

Keystone Symposium: PI 3-Kinase and Interplay with Other Signaling Pathways / Tumor Metabolism

PI 3-Kinase and Interplay with Other Signaling Pathways (X3)

Scientific Organizers: Christian Rommel, Kevan M. Shokat, Jose Baselga

Dates: February 24 - March 1, 2013

Location: Keystone Resort, Keystone, Colorado, USA

How metabolic pathways are regulated to meet the unique needs of tumor cells is not well understood, but mounting evidence suggests that metabolic regulation in cancer cells is intimately linked with the signal transduction pathways that control cell growth and proliferation. The PI3K-Akt-mTOR signaling pathway is one of the primary mechanisms for controlling tumor cell growth, survival, and motility in response to oncogenic signaling and extracellular cues. Genetic events resulting in inappropriate activation of this pathway are common in many cancers and, as a result, are a focus of both basic cancer research and drug discovery efforts in oncology. Although originally modeled as an independent and linear signaling cascade, today it is evident that the PI3K pathway also functions as a central hub for cross-talk in both vertical as well as reciprocal feedback regulation with other important signaling pathways. One of the most exciting advances in the field is the development of new inhibitors against this pathway. However, the rationale for inhibiting individual or multiple isoforms of PI3K/Akt/mTOR signaling remains a subject of intense debate. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI3K- and related pathways in disease, drawing on human pathophysiology and genetics, preclinical models and clinical data with PI3K pathway inhibitors. A joint meeting addressing Tumor Metabolism will enhance opportunities for interdisciplinary interactions.


Source: http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1134


Tumor Metabolism (X4)

Scientific Organizers: Matthew G. Vander Heiden and Karen H. Vousden

Dates: February 24 - March 1, 2013

Location: Keystone Resort, Keystone, CO, USA

Proliferating tumor cells have different metabolic requirements than most normal differentiated cells. All cells consume nutrients to generate ATP and maintain homeostasis, however cell proliferation requires additional nutrient uptake to support macromolecular synthesis needed for cell growth. How metabolic pathways are regulated to balance these needs is not well understood, but mounting evidence suggests that metabolism is actively regulated to support cell growth, and that this regulation is intimately linked with the signal transduction pathways that control cell growth and proliferation. Metabolic changes represent some of the first differences ever noted between tumors and normal tissues. Yet, only recently has it been appreciated that many genetic events associated with cancer result in signal transduction changes to promote metabolism that is conducive to growth. This has accelerated research to understand metabolism in tumors with an eye toward targeting these pathways for improved cancer therapy. Substantial progress in the field has come from laboratories with diverse expertise providing new insights about metabolism and its regulation. However, a deeper understanding of tumor metabolism requires methods to assess metabolite flux and pathway regulation that historically have not been used to study cancer biology. Recent years have seen a remarkable advance in techniques available to interrogate metabolic pathways in vitro and in vivo. This work has been augmented by progress in modeling metabolic networks that facilitate interpretation of complex metabolism data to define key points of regulation. A growing cross talk between these systems biology approaches and traditional cancer biology studies has enabled increasingly sophisticated studies that enhance our understanding of tumor metabolism. Bringing together scientists with expertise in signal transduction, nutrient and oxygen sensing, genetic events affecting metabolism, metabolic flux measurements and network modeling will provide an opportunity to discuss the latest data informing metabolic regulation in tumors. These discussions will impact studies of metabolism in other contexts. Similarly, emerging data related to metabolic regulation in the immune systems can inform studies of tumor metabolism. PI-3 kinase is a critical regulator of metabolism and there have been numerous advances in understanding this signaling pathway; a joint meeting addressing PI-3 Kinase will enrich the dialogue across disciplines to explore how metabolism influences multiple aspects of biology




Source: http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1195