House Secondary Banner
 
You may also want to consider these related products.
Anti-STAT4 (RABBIT) Antibody - 100-401-861
Anti-STAT4 (RABBIT) Antibody - 100-401-861
Anti-STAT5 pY694 (MOUSE) Monoclonal Antibody - 200-301-A45
Anti-STAT5 pY694 (MOUSE) Monoclonal Antibody - 200-301-A45
Anti-STAT5 pY694 (MOUSE) Monoclonal Antibody - 200-301-B18
Anti-STAT5 pY694 (MOUSE) Monoclonal Antibody - 200-301-B18
Anti-STAT2 (MOUSE) Monoclonal Antibody - 200-301-B65
Anti-STAT2 (MOUSE) Monoclonal Antibody - 200-301-B65
Primary Antibodies  >  Cytokines & Growth Factor Antibodies
 

STAT6 phospho Y641 Antibody

Rabbit Polyclonal
Code

600-401-C67
Size

100 µg
Price

$309.00
Availability

Ships next business day.
Order Offline:
Phone: 800.656.7625
E-mail: orders@rockland-inc.com
Fax: 610.367.7825
Bulk Orders:
Call or E-mail Us For Information
Fill out our Contact Form
Western Blot of Rabbit anti-STAT6 pY641 antibody.  
Lane 1: unstimulated Hela cell lysate.  
Lane 2: IL-4 stimulated Hela cell lysate.  
Load: 10 µg per lane.
Primary antibody: STAT6 pY641 antibody at 1:1000 for overnight at 4°C.
Secondary antibody: HRP goat anti-rabbit at 1:40,000 for 30 min at RT.
Block: 5% Blotto, 30 min at RT.
Predicted/Observed size: 94 kDa, 90 kDa. 
Other band(s): unspecific bands.
Shipping & Handling Fees Apply.

Shipping:
$85.00 to United States
Handling:
$20.00
Synonyms: Signal transducer and activator of transcription 6 antibody, IL-4 Stat antibody

STAT6 phospho Y641 Antibody Properties

Description
Anti-STAT6 pY641 (RABBIT) Antibody - 600-401-C67
Host
Rabbit
Target Species
Human
Known Cross Reactivity
human
Clonality
Polyclonal
Application
ELISA : 1:32,000
Western Blot : 1:1000
Other Dilution: User Optimized
Physical State
Liquid (sterile filtered)
Shipping condition
Dry Ice
Format
IgG
Label
Concentration
1.13 mg/mL by UV absorbance at 280 nm
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% (w/v) Sodium Azide
Stabilizer
None
GeneName
STAT6
Related Links
Download CofA
Lot#  

STAT6 phospho Y641 Antibody Description

Background
Anti-STAT6 phospho Y641 Antibody is ideal to study STAT6. STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is involved in interleukin-4 signaling. It interacts with NCOA1 via its C-terminal LXXLL motif. Further it induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Following stimulation by IL-4 and IL-3, Stat6 is activated via phosphorylation at Tyr641 and translocates to the nucleus where it regulates cytokine-induced gene expression. STAT6 research areas include Immunology, Signal Transduction and Chromatin & Nuclear Signaling.
Immunogen
STAT6 phospho Y641 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Y641 of human STAT6 protein.
Immunogen Type
Peptide
Post Translational Modification
Phosphorylation
Storage Condition
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Application Note
This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 94.1kDa in size corresponding to STAT6 pY641 protein by western blotting in the appropriate cell lysate or extract.
Purity/Specifity
This affinity purified antibody is directed against human STAT6 pY641 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with STAT6 pY641 protein from human at 100% based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Disclaimer Note-General
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 326, Gilbertsville, Pennsylvania, USA.
General Reference
Li Z , Jiang J. (2008) Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer Res.Nov 1;68(21):8687-94. Wang HW, Joyce JA. (2010) Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions. Cell Cycle.Dec 15;9(24):4824-35. Epub 2010 Dec 15.
Specific Reference
Log in to submit your product review.

Product Type
Primary Antibodies;
Applications
ELISA, WB
Reacts With
mouse
Catalog Number
100-401-861

Product Type
Primary Antibodies;
Applications
ELISA, WB, IHC, IF
Reacts With
human, mouse, rat
Catalog Number
200-301-A45

Product Type
Primary Antibodies;
Applications
ELISA, WB, IHC, IF
Reacts With
human, mouse, rat
Catalog Number
200-301-B18

Product Type
Primary Antibodies;
Applications
ELISA, WB, IHC
Reacts With
human, mouse
Catalog Number
200-301-B65

Product Label

 

Description
Unconjugated
Color
Conjugation Reference
Molecular Weight
Excitation Wavelength
Conjugation Chemistry