IDO2 antibody recognizes Indoleamine 2,3-dioxygenase 2 (IDO2). IDO2 is related to IDO1, and may play a role in T and B cell immunity. IDO2 is expressed in a few select cell types and levels of protein expression appear to be very low, perhaps below the level of detection by IHC. It is detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO2 catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Activity of IDO2 is inhibited by 1MT (1-methyl-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan). D-1mT (1-methyl-D-tryptophan) may be an indirect inhibitor of the IDO2 pathway. Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics.
IDO2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a mixture of human and mouse full length protein corresponding to IDO2.