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Acetylation is a key component in the regulation of gene expression. HDAC enzymes are involved in removing the acetyl group from the histones containing the nucleosome. Other proteins known to be involced in the deacetylation of proteins are SIRTs. In general, hyperacetylation is associated with increased transcriptional activity, whereas decreased levels of acetylation (hypoacetylation) are associated with repression of gene expression. Steady-state levels of acetylation of the core histones result from the balance between the opposing activities of histone acetyltransferases and histone deacetylases (HDACs). In addition to deacetylation of histones, HDACS also are known to deacetylate other proteins including p53 (600-401-H09; 600-401-E04; 200-301-174), a-tubulin, E2F and MyoD. Class I HDACs are found almostexclusively in the nucleus while class II HDACs are able to shuttle in and out of the nucleus in response to certain cellular signals. The table below illustrates which HDAC proteins belong to each class.
Rockland produces HDAC antibodies under rigorous quality control testing. This ensures that the finished product meets or exceeds our high standards for optimum performance in your assays.
Rockland offers a variety of choices of HDAC antibodies and buffers to use in histone specific assays including:
HDAC9 Antibody (internal)
HDAC9 Antibody (N-terminal)
HDAC Assay Buffer
View the Rockland & Leica HDAC Poster
Rockland Immunochemicals Inc.Limerick, PA 19468E-mail: email@example.comPhone: 800.656.7625