Phosphorylated State Proteins - 3. AKTs and Related Targets

The Akt family of serine-threonine kinases consists of three members: Akt-1, Akt-2 and Akt-3. All Akt family members share a common structure with an N-terminal plekstrin domain, a central kinase domain and C-terminal hydrophobic domain. The Akt family members are not redundant and regulate a broad spectrum of cellular functions. To be fully activated, Akt requires phosphorylation at two specific sites: threonine 308 and serine 473. Upon activation, Akt moves from the membrane to the cytoplasm and nucleus where it phosphorylates its target.

• Phospho specific antibodies to pAKT
• Phospho specific antibodies to AKT related proteins

Phosphorylated State Proteins

1. Background
2. Pathways Covered at Rockland
3. AKTs 
4. Phospho specific Antibodies
5. Western Blot, Immunohistochemistry and Immunofluorescence
6. Tailored Phosphorylated Target