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Primary antibodies are developed to specifically detect a particular antigen of interest. Among the various biomolecules under investigation by researchers, specific antigens of choice could be of the following nature: protein, peptide, carbohydrate or other small molecules. If specifically developed, primary antibodies can be developed to recognize a modification such as phosphorylation, methylation, glycosylation or acetylation.
The assay format into which these primary antibodies are integrated determines their application as non-conjugated or reporter (enzyme or fluorophore) labeled format. Conjugated primary antibodies are useful because they eliminate the need for a detection (secondary) antibody. Primary antibodies bind with high affinity and specificity, and are extremely useful for the detection of biomarkers. Primary antibodies are a crucial component in diagnostic tests for the detection of Parkinson's and Alzheimer’s disease. Primary antibodies can also be used to recognize antigens in numerous types of assay formats including Western Blot, Enzyme -Linked Immunosorbent Assay (ELISA), Analytical Cytology, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Chromatin Precipitation (ChIP), Crystallography, Surface Plasmon Resonance (SPR), Neutralization and others.
Apolipoproteins are the protein components of lipoprotein particles. At least nine distinct polymorphic forms of apolipoproteins are known to exist in serum where they bind lipids such as cholesterol. Apolipoproteins transport lipids throughout the circulatory and lymphatic systems. Apolipoproteins also function as enzyme cofactors and receptor ligands as well as lipid carriers and are involved in the metabolism of lipids and their uptake into tissue and organs.
Antibodies to cancer can be extremely diverse, while also highly specific make this a rich area of research for drug companies and leading cancer researchers alike. Rockland's phospho specific conjugated antibodies are useful because they eliminate the need for a secondary antibody.
Primary antibodies are useful tools to detect specific biomolecules and measure cellular changes in their level and specificity of modification. Rockland creates a number of primary antibodies that can help identify cardiovascular changes identified in a number of scientific disciplines, including analytical cytology, cell biology and molecular biology.
Primary antibodies are extremely useful for the vast fields of Cell Biology and proteasome research. Cell processes such as apoptosis, cell stress, cell cycle progression, cell signaling, cytoskeleton and extracellular matrix (ECM) organization, gene expression, metabolism, protein synthesis and degradation, enzyme phenotype profiling and ion channel transport are crucial for researchers to understand the full cell cycle.
The superfamily of proteins regulating the eukaryotic cell cycle include cyclins, cyclin dependent kinases and tumor suppressor proteins which act as stimulators or potent negative modulators. Numerous proteins involved in these mechanisms are worthy of study because regulation occurs at different levels. Recent studies have examined the consequences of epigenetic marks and cell cycle control leading to more research on the cells’ divisional fate and its relationship to cancer.
Genetic expression is brought about through differences in the DNA sequence, histone modifications, and DNA methylation. Rockland creates some of the most sensitive and accurate primary antibodies available. We have proteins, kits and reagent products to help continue chromatin and nuclear signaling research in today’s market.
Rockland offers an excellent selection of primary antibodies for developmental biology research. Our process ensures accurate, repeatable results, every time. Our comprehensive selection includes transcription factors and growth factors utilized for cell differentiation and proliferation.
Rockland continues to innovate and drive thought leadership in antibody science, as well as the technology important to the future of the industry. Rockland offers an extensive antibody portfolio encompassing antibody probes specific to Epigenetics.
Rockland produces a number of primary antibodies useful in the immunology field, helping researchers identify new discoveries every day. Cytokines are extensively used in cellular communication regulating immune functions and embryogenesis.
Rockland is a trusted leader in microbiology primary antibody manufacture and production, utilizing high quality immunological reagents to produce numerous primary antibodies, secondary antibodies, monoclonal and polyclonal antibodies and related products for all walks of researchers. Compromise elsewhere. Protect your next project with Rockland microbiology primary antibodies.
Rockland produces a number of highly specific antibodies for neuroscience research that have undergone the most rigorous quality tests in the industry. Our products are validated for multiple applications, including protein targets important in the study of protein trafficking, axon guidance, dendrite development, neuronal migration, neurotrophins, apoptosis, and synaptogenesis.
Cellular processes are regulated through powerful mechanisms developed through signal transduction pathways that generate changes in gene expression. Rockland offers a suite of primary antibody products to help study this pathway and the mechanisms that act on it.
Rockland produces a number of primary antibodies for mesenchymal stem cell research, providing the sensitivity researchers need combined with the accuracy they demand. We also offer custom conjugation of any antibody to the fluorophore of choice, allowing researchers to fully develop customized research projects to continue innovating research in a variety of fields.
Virology is the study of viruses, complexes of nucleic acids and proteins that have the capacity for replication in animal, plant, and bacterial cells. Rockland offers a suite of primary antibody products to help study viruses and their mechanisms of infection. Rockland's virology antibodies yield reproducible results and lead to significant advances in the field.
The Mouse TrueBlot® Western Blot Kit contains the critical supporting reagents, buffers, and substrates for GFP immunoprecipitation and Western blotting of samples using TrueBlot second step immunoblotting reagents in conjunction with your own primary IP antibody and primary (Mouse IgG) Western blotting antibody. TrueBlot technology enables unhindered detection of protein bands of interest which would otherwise be obscured by the presence of reduced and denatured heavy and light chain immunoglobulin in the blot (as detected by the conventional immunoblotting HRP anti-mouse IgG reagent).
Rockland Immunochemicals Inc.Gilbertsville, PA 19525E-mail: email@example.comPhone: 800.656.7625