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Primary antibodies are developed to specifically detect a particular antigen of interest. Among the various biomolecules under investigation by researchers, specific antigens of choice could be of the following nature: proteins, peptides, carbohydrates or other small molecules. If specifically developed, primary antibodies can be developed to recognize a modification such as post translational modifications including phosphorylation, methylation, glycosylation or acetylation, making these antibodies great tools to study and distinguish proteins that are activated, silenced, processed and or may cause disease.
The assay format of these primary antibodies determines their application i.e. unconjugated or conjugated to a reporter (an enzyme or fluorophore). Conjugated primary antibodies are useful because they eliminate the need for a detection secondary antibody. Primary antibodies bind with high affinity and specificity, and are extremely useful for the detection of biomarkers. Primary antibodies are a crucial component in diagnostic tests for the detection of Parkinson's and Alzheimer’s disease. Primary antibodies can also be used to recognize antigens in numerous types of assay formats including Western Blot, Enzyme -Linked Immunosorbent Assay (ELISA), Analytical Cytology, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Chromatin Precipitation (ChIP), Crystallography, Surface Plasmon Resonance (SPR), Neutralization and others.
Primary Antibody Categories:
Apolipoproteins are the protein components of lipoprotein particles. At least nine distinct polymorphic forms of apolipoproteins are known to exist in serum where they bind lipids such as cholesterol. Apolipoproteins transport lipids throughout the circulatory and lymphatic systems. Apolipoproteins also function as enzyme cofactors and receptor ligands as well as lipid carriers and are involved in the metabolism of lipids and their uptake into tissue and organs.
Rockland produces a number of primary antibodies for apoptosis and biochemical events that lead to the specific morphology of programmed cell death. We also offer various products to study the intracellular machinery responsible for apoptosis including antibodies to caspases, pro-caspase regulation and IAP (inhibitor of apoptosis) family proteins.
Antibodies to cancer can be extremely diverse, while also highly specific make this a rich area of research for drug companies and leading cancer researchers alike. Rockland's phospho specific conjugated antibodies are useful because they eliminate the need for a secondary antibody.
Primary antibodies are useful tools to detect specific biomolecules and measure cellular changes in their level and specificity of modification. Rockland creates a number of primary antibodies that can help identify cardiovascular changes identified in a number of scientific disciplines, including analytical cytology, cell biology and molecular biology.
Primary antibodies are extremely useful for the vast fields of Cell Biology and proteasome research. Cell processes such as apoptosis, cell stress, cell cycle progression, cell signaling, cytoskeleton and extracellular matrix (ECM) organization, gene expression, metabolism, protein synthesis and degradation, enzyme phenotype profiling and ion channel transport are crucial for researchers to understand the full cell cycle.
The superfamily of proteins regulating the eukaryotic cell cycle include cyclins, cyclin dependent kinases and tumor suppressor proteins which act as stimulators or potent negative modulators. Numerous proteins involved in these mechanisms are worthy of study because regulation occurs at different levels. Recent studies have examined the consequences of epigenetic marks and cell cycle control leading to more research on the cells’ divisional fate and its relationship to cancer.
Genetic expression is brought about through differences in the DNA sequence, histone modifications, and DNA methylation. Nuclear signaling regulated by transcription factors (TF), that directly bind to the DNA to turn specific gene expression on or off, and TF-binding proteins allow that all the cells in the body can function corresponded to their position. Rockland creates some of the most sensitive and accurate primary antibodies available including a vast array of NfkB signaling and STAT signaling antibodies and reagents. We have proteins, kits and reagent products to help continue chromatin and nuclear signaling research
Rockland offers an excellent selection of primary antibodies for developmental biology research. Our process ensures accurate, repeatable results, every time. Our comprehensive selection includes transcription factors and growth factors utilized for cell differentiation and proliferation.
Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body systems. Rockland’s DNA Damage and Repair Antibodies are used to study the collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. Rockland antibodies provide the sensitivity researchers need combined with the accuracy they demand.
Rockland continues to innovate and drive thought leadership in antibody science, as well as the technology important to the future of the industry. Rockland offers an extensive product portfolio encompassing antibody probes and specific peptides specific to Epigenetics.
Primary antibodies to key components identified in glucose metabolism and energy metabolism facilitate research of various human diseases including diabetes, fatty acid storage disease, glycogen storage disease, hyperlipidemia, hypercholesterolemia and cancer. Rockland produces antibodies to study glucose metabolism and energy metabolism to enable research scientists to better understand the relationship between glucoregulation, energy production (aerobic respiration) and disease. For instance, antibodies to IRS1, Muscle Glycogen Synthase and Myosin Light Chain allow investigators to study insulin uptake, glycogen storage and smooth muscle myosin phosphorylation, respectively.
Rockland is a trusted leader in microbiology primary antibody manufacture and production, utilizing high quality immunological reagents to produce numerous primary antibodies, secondary antibodies, monoclonal and polyclonal antibodies and related products for all walks of researchers. Compromise elsewhere. Protect your next project with Rockland microbiology primary antibodies.
Rockland produces a number of highly specific antibodies for neuroscience research that have undergone the most rigorous quality tests in the industry. Our products are validated for multiple applications, including protein targets important in the study of protein trafficking, axon guidance, dendrite development, neuronal migration, neurotrophins, apoptosis, synaptogenesis and Notch signaling antibodies and reagents.
Phosphorylation involves the addition of phosphate groups to proteins, most commonly at a serine (S), threonine (T) or tyrosine (Y) residue by a kinase and is essential for pathway regulation, cell signaling and growth. At Rockland, we have developed a vast and diverse portfolio of poly and monoclonal phospho specific antibodies and reagents that allow scientists to track and quantify phospho proteins using a wide range of techniques such as phospho immunoprecipitation, western blot, flow cytometry, immunohistochemistry and immunofluorescence.
Serum Protein Components or blood proteins are proteins present in blood plasma. Rockland offers a number of primary antibodies to detect numerous of the serum proteins in a variety of species including human, bovine, dog, mouse and rabbit.
Cellular processes are regulated through powerful mechanisms developed through signal transduction pathways that generate changes in gene expression. Rockland offers a suite of highly sensitive and accurate primary antibodies recognizing Kinases and Phosphatases, including antibodies to study signaling pathways and related mechanisms. Rockland produces antibodies and reagents for AKT signaling, NfkB signaling, Notch signaling, and STAT signaling.
Rockland produces a number of primary antibodies for mesenchymal stem cell research, providing the sensitivity researchers need combined with the accuracy they demand. We also offer custom conjugation of any antibody to the fluorophore of choice, allowing researchers to fully develop customized research projects to continue innovating research in a variety of fields.
Rockland Immunochemicals Inc.Limerick, PA 19468E-mail: email@example.comPhone: 800.656.7625