Primary antibodies are raised against an antigenic target of interest and can be focused on a protein, peptide, or carbohydrate. By focusing research on specific proteins, such as those found within the extracellular matrix, researchers can better understand various cellular functions, including cellular adhesion, differentiation, and survival (for more information on collagen and other ECM proteins, visit our Collagen Antibodies page).
Most primary antibodies are unconjugated and readily bond with high affinity and specificity to unique epitopes across a broad spectrum of biomolecules. Primary antibodies are available as high specificity monoclonal antibodies and/or as polyclonal antibodies. Typically, primary antibodies are useful not only to detect specific biomolecules but also to measure changes in their level and specificity of modification. Monitoring processes tend to include phosphorylation, methylation, or glycosylation, while research testing focuses on the detection of biomarkers for disease.
Research is actively pursued on cancer, cell biology, and neuroscience utilizing primary antibody products. Primary antibodies can also be used for the study of ADME and multi-drug resistance (MDR) of therapeutic agents.