Events Detail:

Keystone Symposium: Neurogenesis / New Frontiers in Neurodegenerative Disease Research

Neurogenesis (J7)

Scientific Organizers: Hongjun Song, Yukiko Gotoh, Yi Eve Sun, and Gerd Kempermann

Dates: February 3 - 8, 2013

Location: Santa Fe Community Convention Center, Santa Fe, New Mexico, USA 

 Formation of the nervous system starts with neurogenesis from neural stem cells in the developing embryo and continues throughout life in discrete regions of the adult brain. Defects in developing and adult neurogenesis have been implicated in various mental disorders and degenerative neurological diseases. In recent years, tremendous progress has been made in understanding the cellular and molecular mechanism regulating neurogenesis from neural stem cells/progenitors in the developing and adult brain. This meeting will gather an interdisciplinary group of scientists using various experimental model systems to highlight the latest advances in the neurogenesis field, including understanding of novel genetic and epigenetic mechanisms regulating developing and adult neurogenesis, disease modeling using patient-derived induced pluripotent stem cells, and identification of potential functions of adult neurogenesis and its contribution to mental disorder and degenerative neurological disorders. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent Keystone Symposia meeting on New Frontiers in Neurodegenerative Disease Research, which will share two plenary sessions with this meeting. In combination, these meetings will provide a platform for both speakers and participants to initiate extensive discussion and promote scientific collaborations on new directions.



New Frontiers in Neurodegenerative Disease Research (J8)

Scientific Organizers: Li-Huei Tsai, Steven M. Paul, and Michael Hutton

Dates: February 3 - 8, 2013

Location: Santa Fe Community Convention Center, Santa Fe, New Mexico, USA

It has been more than two decades since genes causing familial Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, motor neuron disease and other neurodegenerative disorders were identified. While numerous molecular and cellular events contributing to these devastating illnesses have been revealed, key pathological events and feasible targets for therapeutic intervention still elude us. Increasing evidence supports that mechanisms underlying neuronal demise may be shared amongst multiple neurodegenerative disorders. For example, compromised mitochondria function, although prominent in Parkinson’s disease, is also shared in Alzheimer’s and amyotrophic lateral sclerosis. Emerging evidence also indicates a negative influence of neurotoxic stress upon the epigenome, and that the restoration of the epigenome can be beneficial for cognition. Recent insights into the relationship between genome integrity and the aging brain have emphasized the role of DNA damage and repair in neuronal function. Particularly intriguing are the recent observations that protein misfolding can have either beneficial or detrimental effects and that misfolded proteins implicated in several neurodegenerative disease can propagate themselves. New tools for the study of neurodegenerative disorders include the use of human neurons derived from induced pluripotent stem cells (iPSCs) in addition to advances in the field of biomarkers and functional imaging. This meeting aims to address emerging areas in neurodegenerative disease research that may reveal novel mechanisms and targets for therapeutic intervention. It bring together experts studying various degenerative diseases using diverse approaches to provide reviews of up-and-coming areas in these fields and inspire new insights and approaches to the battle against neurodegenerative disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Neurogenesis, which will share two plenary sessions with this meeting.