Primary Antibodies  >  Phospho Specific Antibodies

GABA(A) Receptor gamma 2 phospho S327 Antibody

Rabbit Polyclonal
NCI Collaboration JCYIA Product
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  • Western Blot of Anti-GABA(A) Receptor gamma 2 pS327 (Rabbit) Antibody - 612-401-D52
100 µL
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GABA(A) Receptor gamma 2 phospho S327 Antibody Properties

Anti-GABA(A) Receptor gamma 2 pS327 (Rabbit) Antibody - 612-401-D52
Target Species
Known Cross Reactivity
Western Blot : 1:1000
Physical State
Shipping Condition
Dry Ice
0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol
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GABA(A) Receptor gamma 2 phospho S327 Antibody Description

Anti-GABA(A) Receptor gamma 2 pS327 Antibody detects phosphorylated GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. It has recently been suggested that PKC? regulates the sensitivity of GABAA alpha1-beta2-gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2. GABA(A) Receptor gamma2 pS327 antibody is ideal for investigators involved in Neuroscience.
Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2
Anti-GABA(A) Receptor gamma 2 pS327 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327.
Immunogen Type
Post Translational Modification
Storage Condition
Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Application Note
Anti-GABA(A) Receptor gamma 2 pS327 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 45 kDa in size corresponding to GABA(A) receptor gamma 2 subunit phosphorylated at Ser327 in the appropriate cell lysate or extract.
Anti-GABA(A) Receptor gamma 2 pS327 Antibody is directed against rat phosphorylated GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAA band is completely blocked by lambda-phosphatase treatment. This antibody is directed against rat GABA(A) receptor gamma 2 proteins phosphorylated at Ser327. Cross reactivity with GABA(A) Receptor gamma 2 pS327 from other sources has not been determined.
Disclaimer Note-General
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
General Reference
Olsen RW and Tobin AJ (1990). Molecular biology of GABAA receptors. FASEB 4:1469-1480. Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJS, Thompson SA and Wafford KA (1999). Molecular and functional diversity of the expanding GABAA receptor gene family. Ann NY Acad Sci 868:645-653. Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W and Sieghart W (2004). Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor ?2-subunit. Biochem Pharmacol 68:1621-1629. Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM and Messing RO (2007). Protein kinase Ce regulates ?-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of ?2 subunits. J Biol Chem 282(45):33052-63.
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Product Type
Primary Antibodies;
Reacts With
human, rat and mouse
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Supporting Reagents;
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