focuses on the study of the nervous system and its structural and functional
organization. It incorporates several scientific disciplines that approach
different aspects of the nervous system including cellular and molecular biology, development, physiology, evolution
and behavioral science among others.
reports from the World HealthOrganization (WHO) shows that different types of
neurological disorders can affect up to one billion people worldwide. Common
neurological disorders such as dementia, epilepsy, headache disorders, multiple
sclerosis, Parkinson’s disease, stroke and traumatic brain injuries are now
considered very important public health problems that affect both developed and
developing countries. Elucidating the nature of these pathologies and how to
manage and treat them properly has been critical in propelling neuroscience
research globally. An important aspect of such research is the identification
and characterization of key molecules that can be used as biomarkers for both
the assessment of patients at risk of neurological disorders and also as
targets for novel therapeutic approaches.
The study of the nervous system includes
multiple signaling pathways involving the Beta-amyloid isomers Aß40 and Aß42 metabolism, oxidative stress, blood barrier, dopamine signaling, and gamma-aminobutyric acid (GABA) interactions among many others. Rockland also
has available antibodies specific to research involving the underlying causes
in the onset and progression of neurodegenerative disorders like Alzheimer's
disease. Included in Rockland's portfolio of antibodies are probes specific to Beta-amyloid isomers Aß40 and Aß42, as well as an array of full-length and
truncated isomer-specific peptides displaying characterized mutations.
research relies heavily on antibodies that can help identify and elucidate
reactions on the cellular, molecular and biochemical level, which may lead to a
better understanding of a variety of neuroscience processes and neuronal
diseases. Antibody-based approaches for isolation, characterization and localization
of target proteins are among the most critical and widely used techniques in
molecular and cellular neuroscience, leading to rapid development in our
knowledge of protein abundance, distribution, structure, and function.
antibodies exhibit high specificity, selectivity and reproducibility
by Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) and ELISA. These antibodies are
routinely used for characterization of neural
development, stem cell
and differentiation, neural transmission,
disease and neuroinflammation.
demonstrated experience in development and validation of multiple assay
formats, Rockland scientists continuously deliver optimized immunoassays for neuroscience.
In particular, ELISA kits provide a valuable, efficient solution for
determination of critical targets involved in neural development, synaptic
signaling and neurodegeneration. Rockland’s AccuSignal ELISA Kits guarantee
high precision, accuracy, sensitivity, and specificity. Each neuroscience
ELISA kit is optimized for accurate quantitation of targets in various
sample types, including serum, plasma, saliva, cell lysates, and/or cell
culture supernatants. Additionally, cell viability assays further complement a
broad suite of tools for deep characterization of neuronal signaling pathways.
Rockland offers a wide range of
recombinant proteins and peptides from human, mouse and other species that can be used in a variety of
assays as controls or for other purposes since they exhibit a ≥90% purity.
Alternatively, scientists can also take advantage of Rockland’s Custom
Services for reliable generation
of tailored proteins and antibodies among others.
Rockland Immunochemicals Inc.Limerick, PA 19468E-mail: email@example.comPhone: 800.656.7625