Stem Cell Antibodies

A stem cell is a cell that has the potential to develop into numerous different cell types during animal development, early life and growth. Additionally they serve as a repair system in various tissues, dividing essentially without limit to replenish other cells during the animal life cycle. Stem cells are distinguished from other cell types by two characteristics: 

Self-Renewal: Stem cells are unspecialized cells capable of renewing themselves through cell division, even after long periods of inactivity.

Potency: Stem cells have the capacity to be induced to differentiate and become tissue- or organ-specific cells with specialized functions.

Cell Fate in Animal Tissue

 Figure 1: Schematic drawing of the cell fate in animal tissue ( 



Featured Stem Cell Antibodies:


View all Stem Cell antibodies             View all Stem Cell Proteins  

Antibodies to stem cells facilitate stem cell research.  Stem cell research remains a growing area of scientific exploration, with numerous possibilities in various medical fields and disease treatments. Each differentiation state has specific markers that can be used to isolate or identify differentiated vs. non differentiated cells (see figure 2).



Differentiation Markers    Figure 2: Schematic drawing of differentiation markers. Rockland offers several antibodies to detect biomarkers for pluripotency or differentiation state. Some of the recommended markers are: OCT4, Nanog, GATA4



Oct-4 is a protein that is critically involved in the self-renewal of undifferentiated embryonic stem cells and is used as a marker for pluripotent cells. Oct-4 expression must be closely regulated as too much or too little will cause differentiation of the cells. Rockland's Oct 4 antibody recognizes the pluripotency marker Oct4, expressed in Embryonic Stem Cells and Embryonic Germ Cells. Other recommended markers are: Nanog and GATA4.

Rockland produces primary antibodies against stem cell biomarkers suitable for bioimaging, immunofluorescence microscopy, multiplex protein assays, ELISA, and Western blot analysis. These antibodies and antibody based tools include a rapidly expanding portfolio of flow cytometry reagents as well as antibodies, buffers, and protocols for cell signaling analysis. Research in developmental biology has led to the discovery of several types of stem cells, including embryonic stem cells, embryonic germ cells and adult stem cells.


Quality Production

New methods for immunogen production, animal immunization, and antibody generation, purification and validation have matured such that it is now possible to generate antibodies against a wide range of target proteins, regardless of their biochemical characteristics or natural abundance. Each step of the antibody development process is completed within our in-house, controlled environment, delivering unsurpassed repeatability in antibody construction. Each component used in our manufacturing process is developed within our own facilities, ensuring that each step of the process can be certified and verified multiple times. Our goal is to provide accountability and repeatable test results with each antibody we develop.


Stem Cell Antibody Applications

Western Blot Assays
Flow Cytometry
Immunofluorescence Assays

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