Primary Antibodies

Primary Antibodies


Primary antibodies are immunoglobulins that bind to a specific antigen (protein, peptide, small molecule, etc.) of interest and are typically unconjugated. A good primary antibody recognizes and binds with high affinity and specificity to purify, detect, and measure the antigen. Using a variety of hosts, such as mouse, rabbit, goat, or chicken, primary antibodies are available as polyclonal or monoclonal depending upon the application. Primary antibodies can be developed to recognize post-translational modifications (PTMs) including phosphorylation, methylation, glycosylation, or acetylation, making these antibodies great tools to study and identify proteins that are activated, silenced, processed, and/or may cause disease. 


  Primary Antibody Diagram


The assay format of these primary antibodies determines their application, i.e. unconjugated or conjugated to a reporter molecule (an enzyme or fluorophore). Conjugated primary antibodies can be useful because they eliminate the need for a detection secondary antibody

Primary antibodies can also be used to recognize antigens in numerous types of assay formats including Western Blot, Enzyme-Linked Immunosorbent Assay (ELISA), Analytical Cytology, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Chromatin Precipitation (ChIP), Crystallography, Surface Plasmon Resonance (SPR), Neutralization, and others.



Primary Antibody Categories: 



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Apolipoprotein Primary Antibodies  


Apolipoproteins are the protein components of lipoprotein particles. At least nine distinct polymorphic forms of apolipoproteins are known to exist in serum where they bind lipids such as cholesterol. Apolipoproteins transport lipids throughout the circulatory and lymphatic systems. Apolipoproteins also function as enzyme cofactors and receptor ligands as well as lipid carriers and are involved in the metabolism of lipids and their uptake into tissue and organs.  


Apolipoprotein Primary Antibodies



Apoptosis Primary Antibodies  


Rockland produces a number of primary antibodies for apoptosis and biochemical events that lead to the specific morphology of programmed cell death. We also offer various products to study the intracellular machinery responsible for apoptosis including antibodies to caspases, pro-caspase regulation and IAP (inhibitor of apoptosis) family proteins.







Cancer Research Primary Antibodies


Antibodies to cancer can be extremely diverse, while also highly specific make this a rich area of research for drug companies and leading cancer researchers alike. Rockland's phospho specific conjugated antibodies are useful because they eliminate the need for a secondary antibody.  


Cancer Primaries





Cardiovascular Primary Antibodies

Primary antibodies are useful tools to detect specific biomolecules and measure cellular changes in their level and specificity of modification. Rockland creates a number of primary antibodies that can help identify cardiovascular changes identified in a number of scientific disciplines, including analytical cytology, cell biology and molecular biology. 


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Cell Biology Primary Antibodies

Primary antibodies are extremely useful for the vast fields of Cell Biology and proteasome research. Cell processes such as apoptosis, cell stress, cell cycle progression, cell signaling, cytoskeleton and extracellular matrix (ECM) organization, gene expression, metabolism, protein synthesis and degradation, enzyme phenotype profiling and ion channel transport are crucial for researchers to understand the full cell cycle.



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Cell Cycle & Checkpoint Control Primary Antibodies


The superfamily of proteins regulating the eukaryotic cell cycle include cyclins, cyclin dependent kinases and tumor suppressor proteins which act as stimulators or potent negative modulators. Numerous proteins involved in these mechanisms are worthy of study because regulation occurs at different levels. Recent studies have examined the consequences of epigenetic marks and cell cycle control leading to more research on the cells’ divisional fate and its relationship to cancer.



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Chromatin & Nuclear Signaling Primary Antibodies


Genetic expression is brought about through differences in the DNA sequence, histone modifications, and DNA methylation. Nuclear signaling regulated by transcription factors (TF), that directly bind to the DNA to turn specific gene expression on or off, and TF-binding proteins allow that all the cells in the body can function corresponded to their position. Rockland creates some of the most sensitive and accurate primary antibodies available including a vast array of NfkB signaling and STAT signaling antibodies and reagents. We have proteins, kits and reagent products to help continue chromatin and nuclear signaling research 

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Developmental Biology Primary Antibodies


Rockland offers an excellent selection of primary antibodies for developmental biology research. Our process ensures accurate, repeatable results, every time. Our comprehensive selection includes transcription factors and growth factors utilized for cell differentiation and proliferation. 


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DNA Damage and Repair Antibodies


Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body systems. Rockland’s DNA Damage and Repair Antibodies are used to study the collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. Rockland antibodies provide the sensitivity researchers need combined with the accuracy they demand.


DNA Damage & Repair



Epigenetic Antibodies


Rockland continues to innovate and drive thought leadership in antibody science, as well as the technology important to the future of the industry. Rockland offers an extensive product portfolio encompassing antibody probes and specific peptides specific to Epigenetics.


Epigenetic Primary Antibodies


Glucose and Energy Metabolism Primary Antibodies


Primary antibodies to key components identified in glucose metabolism and energy metabolism facilitate research of various human diseases including diabetes, fatty acid storage disease, glycogen storage disease, hyperlipidemia, hypercholesterolemia and cancer.  Rockland produces antibodies to study glucose metabolism and energy metabolism to enable research scientists to better understand the relationship between glucoregulation, energy production (aerobic respiration) and disease. For instance, antibodies to IRS1, Muscle Glycogen Synthase and Myosin Light Chain allow investigators to study insulin uptake, glycogen storage and smooth muscle myosin phosphorylation, respectively.


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Immunology and Infectious Disease Primary Antibodies


Rockland produces a number of primary antibodies useful in the immunology and Infectious Disease field, helping researchers identify new discoveries every day. Infectious Disease studies disorders caused by organisms like parasites, fungi, viruses or bacteria and the mechanisms of infection. Cytokines are extensively used in cellular communication regulating immune functions and embryogenesis. Rockland's immunology and Infectious Disease antibodies yield reproducible results and lead to significant advances in the field. 


Immunology and Infectious Disease



Microbiology Primary Antibodies


Rockland is a trusted leader in microbiology primary antibody manufacture and production, utilizing high quality immunological reagents to produce numerous primary antibodies, secondary antibodies, monoclonal and polyclonal antibodies and related products for all walks of researchers. Compromise elsewhere. Protect your next project with Rockland microbiology primary antibodies. 



Serum Protein Component



Neuroscience Primary Antibodies

Rockland produces a number of highly specific antibodies for neuroscience research that have undergone the most rigorous quality tests in the industry. Our products are validated for multiple applications, including protein targets important in the study of protein trafficking, axon guidance, dendrite development, neuronal migration, neurotrophins, apoptosis, synaptogenesis and Notch signaling antibodies and reagents.  


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Post Translational Modification (PTM) Antibodies


Although the generation of PTM antibodies is challenging, at Rockland Immunochemicals scientists have developed proprietary methods for the development of highly specific PTM antibodies that can be used in a wide range of in vitro and in vivo studies of a modified protein, some of which are not easily performed by other approaches, such as MS.


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Serum Protein Component Primary Antibodies


Serum Protein Components or blood proteins are proteins present in blood plasma. Rockland offers a number of primary antibodies to detect numerous of the serum proteins in a variety of species including human, bovine, dog, mouse and rabbit.


Serum Protein Component



Signal Transduction Primary Antibodies


Cellular processes are regulated through powerful mechanisms developed through signal transduction pathways that generate changes in gene expression. Rockland offers a suite of highly sensitive and accurate primary antibodies recognizing Kinases and Phosphatases, including antibodies to study signaling pathways and related mechanisms.   Rockland produces antibodies and reagents for AKT signaling, NfkB signaling, Notch signaling, and STAT signaling.


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Stem Cell Primary Antibodies

Rockland produces a number of primary antibodies for mesenchymal stem cell research, providing the sensitivity researchers need combined with the accuracy they demand. We also offer custom conjugation of any antibody to the fluorophore of choice, allowing researchers to fully develop customized research projects to continue innovating research in a variety of fields. 

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